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Image Search Results
Journal: mAbs
Article Title: Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
doi: 10.1080/19420862.2016.1193660
Figure Lengend Snippet: hFcRn Tg Mouse Strain Comparisons. PK profile results of Tg32 hemizygous and homozygous, Tg276 homozygous, WT C57Bl/6 and FcRn KO mice following administration of (A) mAb 14, (B) mAb 04 and (C) mAb17. (D) PK profile overlay in FcRn KO mice for mAb04 and mAb17. (E) PK parameters for mAb14, mAb04 and mAb17 in NHP and each mouse model. Data is depicted as the mean ± standard deviation for 3-6 animals/group for panels A-D.
Article Snippet: Homogenates were clarified by centrifugation at 4°C, 10,000 × g for 15 min. Calibration standards were prepared by adding recombinant
Techniques: Standard Deviation
Journal: mAbs
Article Title: Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
doi: 10.1080/19420862.2016.1193660
Figure Lengend Snippet: hFcRn Tg32 PK Differentiation in Framework Mutations. CL correlation between (A) Tg32 hemizygous and (B) homozygous mouse to NHP for 4 pairs of parent and FcRn+ mAbs (mAb01, mAb02, mAb07, mAb14) and (C) Summary of CL and T1/2 PK parameters for each parent and FcRn+ mAb in Tg32 hemizygous and homozygous mice and NHP. Statistical significance determined using a Student's paired t-test (*p < 0.05 and ** p < 0.01).
Article Snippet: Homogenates were clarified by centrifugation at 4°C, 10,000 × g for 15 min. Calibration standards were prepared by adding recombinant
Techniques: